Performance evaluation of antimicrobial peptide ll-37 and hepcidin and β-defensin-2 secreted by mesenchymal stem cells

Reza Esfandiyari; Raheleh Halabian; Elham Behzadi; Hamid Sedighian; Ramezan Jafari; Abbas Ali Imani Fooladi

doi:10.1016/j.heliyon.2019.e02652

Performance evaluation of antimicrobial peptide ll-37 and hepcidin and β-defensin-2 secreted by mesenchymal stem cells

Heliyon. 2019 Oct 23;5(10):e02652. doi: 10.1016/j.heliyon.2019.e02652. eCollection 2019 Oct.

Authors

Reza Esfandiyari¹, Raheleh Halabian¹, Elham Behzadi², Hamid Sedighian¹, Ramezan Jafari³, Abbas Ali Imani Fooladi¹

Affiliations

¹ Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
² Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
³ Department of Radiology, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Abstract

Peptides are secreted by different cell types and are trendy therapeutic agents that have attracted attention for the treatment of several diseases such as infections. Antimicrobial peptides exert various mechanisms such as changing cell membrane permeability which leads to inhibition or death of bacterial cells. mesenchymal stem cells (MSCs) are key to produce antimicrobial peptides and to inhibit the growth of pathogens. These cells have been shown to be capable of producing antimicrobial peptides upon exposure to different bacteria. As a result, antimicrobial peptides can be considered as novel agents for the treatment of infectious diseases. The purpose of this review was to investigate the targets and mechanisms of antimicrobial peptides secreted by MSCs.

Keywords: Antimicrobial peptides; Bacteria; Biotechnology; Infectious disease; Mesenchymal stem cells; Microbiology; Molecular biology; Proteins.

Publication types

Review