1 Department of Critical Care Medicine, Anesthesiology, Pediatrics, Bioengineering, and Clinical and Translational Science, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA Department of Neurology and Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA Pacific Northwest Evidence-based Practice Center, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR Pediatric Neurosurgery, BARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ Department of Neurological Surgery, Oregon Health & Science University, Portland, OR Pacific Northwest Evidence-based Practice Center, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR Critical Care Medicine, Children's National Medical Center, Washington, DC Pediatrics, University of Utah, Salt Lake City, UT Department of Neurosurgery, Stanford University, Stanford, CA Department of Pediatrics, British Columbia's Children's Hospital, Clinical Investigator, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada School of Nursing/School of Medicine, Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke University, Durham, NC Anesthesiology & Pain Medicine, Pediatrics, Harborview Injury Prevention and Research Center (HIPRC), University of Washington, Seattle, WA Division of Pediatric Neurology, University of Washington, Seattle Children's Hospital, Seattle, WA.