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, 14 (11), e0224439
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Association Between Cerebral Atrophy and Osteoporotic Vertebral Compression Fractures

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Association Between Cerebral Atrophy and Osteoporotic Vertebral Compression Fractures

In-Suk Bae et al. PLoS One.

Abstract

Purpose: Osteoporotic vertebral compression fractures (OVCFs) have a serious impact on people's health and quality of life. The purpose of this study was to analyze brain volume in patients with osteoporosis using brain magnetic resonance imaging (MRI) and to investigate the relationship with osteoporotic vertebral compression fractures.

Materials and methods: We included 246 patients with osteoporosis who underwent thoracolumbar radiographs and brain MRI at our hospital. Clinical data on age, sex, bone mineral density, height, weight, osteoporosis medication, hypertension, diabetes, alcohol drinking, and smoking were collected. Intracranial cavity, brain parenchyma, and lateral ventricles volumes were measured using brain MRI with a semiautomated tool.

Results: We founded an independent correlation between age and volume percentages of the brain parenchyma and lateral ventricles. We observed a statistically significant decrease in volume percentage of the brain parenchyma and an increase in volume percentage of the lateral ventricles with increasing age. In addition, we confirmed that patients with OVCF showed a significantly lower volume percentage of brain parenchyma than patients without OVCF.

Conclusion: We observed a significant association between OVCF and volume percentage of brain parenchyma. Degeneration of the brain may lead to a high incidence of falls, and OVCF may occur more frequently in patients with osteoporosis.

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow chart for selecting patients who underwent both brain MRI and thoracolumbar radiographs in our hospital.
MRI = magnetic resonance imaging; MPR = multiplanar reconstruction.
Fig 2
Fig 2. Segmentation of the brain parenchyma and lateral ventricles with a 3D-reconstructed model using the 3D slicer and calculation of each volume (red box indicates the volume): Threshold-based methods to segment the (A) brain parenchyma and (B) lateral ventricles; (C) 3D reconstruction of brain parenchyma using the Model Maker function; (D) 3D reconstruction of lateral ventricles using the Model Maker function.
Fig 3
Fig 3. Merged brain parenchyma and lateral ventricles after 3D-reconstructed model using the 3D slicer.
Fig 4
Fig 4. Scatterplot with linear regression line showing the associations between age and volume percentages of (A) brain parenchyma and (B) lateral ventricles.
Fig 5
Fig 5. Boxplots with dot plots of the volume percentages of (A) brain parenchyma and (B) lateral ventricles according to OVCF.
OVCF = Osteoporotic vertebral compression fracture.

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Grant support

This work was supported by the research fund of Hanyang University (HY- 2018). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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