Changes in health-related quality of life with intensive behavioural therapy combined with liraglutide 3.0 mg per day

Clin Obes. 2019 Dec;9(6):e12340. doi: 10.1111/cob.12340. Epub 2019 Nov 5.


This study examined the effects of intensive behavioural therapy (IBT) for obesity (IBT-alone), IBT plus liraglutide 3.0 mg/day (IBT-liraglutide), and IBT-liraglutide combined with 12 weeks of a portion-controlled diet (Multicomponent) on changes in general health-related (HR) quality of life (QoL) and weight-related QoL. Adults with obesity (79.3% female; 54.0% white; 44.7% black; mean age = 47.6 ± 11.8 years and body mass index = 38.4 ± 4.9 kg/m2 ) were randomized to IBT-alone (n = 50), IBT-liraglutide (n = 50) or Multicomponent (n = 50). General HRQoL was measured with the Short Form-36 (SF-36), and weight-related QoL was assessed with the Impact of Weight on Quality of Life-Lite scale. At week 52, participants in the three groups lost 6.1 ± 1.3%, 11.5 ± 1.3% and 11.8 ± 1.3% of initial body weight, respectively. Both liraglutide-treated groups were significantly more likely than IBT-alone to achieve clinically meaningful improvements in total weight-related QoL. They also both achieved greater improvements than IBT-alone in weight-related public distress and in general mental health, as measured by the SF-36 mental component summary score. Independent of treatment group, greater categorical weight loss was associated with greater improvements in several domains of both general and weight-related QoL. The addition of liraglutide to IBT appeared to improve aspects of both general HRQoL and weight-related QoL.

Keywords: behavioural strategies; glucagon-like peptide 1; psychosocial; quality of life; weight control.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Anti-Obesity Agents / administration & dosage*
  • Behavior Therapy*
  • Combined Modality Therapy
  • Female
  • Humans
  • Liraglutide / administration & dosage*
  • Male
  • Middle Aged
  • Obesity / drug therapy
  • Obesity / psychology
  • Obesity / therapy*
  • Quality of Life
  • Weight Loss / drug effects
  • Young Adult


  • Anti-Obesity Agents
  • Liraglutide