Mitochondrial retrograde signaling to the endoplasmic-reticulum regulates unfolded protein responses

Keisuke Takeda; Shigeru Yanagi

doi:10.1080/23723556.2019.1659078

Mitochondrial retrograde signaling to the endoplasmic-reticulum regulates unfolded protein responses

Mol Cell Oncol. 2019 Sep 11;6(6):e1659078. doi: 10.1080/23723556.2019.1659078. eCollection 2019.

Authors

Keisuke Takeda¹, Shigeru Yanagi¹

Affiliation

¹ Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.

Abstract

Unfolded protein response (UPRs) directs adaption or apoptosis depending on the severity of endoplasmic-reticulum (ER) stress. We found that apoptotic signaling by inositol requiring enzyme 1α (IRE1α), a transducer of UPRs, is suppressed by mitochondrial ubiquitin ligase MITOL/MARCH5 on ER-mitochondria contacts, suggesting that mitochondria regulate cell fate under ER stress.

Keywords: ER stress; ER-mitochondria contact site; IRE1α; MITOL/MARCH5; UPR; Word.