Structure and function of a monocarboxylate transporter homolog specific for L-lactate

Mol Cell Oncol. 2019 Aug 27;6(6):e1646605. doi: 10.1080/23723556.2019.1646605. eCollection 2019.

Abstract

Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structure-function analysis provides insights into the molecular working mechanisms of ligand binding and L-lactate transport.

Keywords: L-lactate transporter; SLC16 family; monocarboxylate transporter; structure; transport mechanism.

Grant support

The project was financially supported by the University of Bern, the Swiss National Science Foundation (grant 310030_184980 to Dimitrios Fotiadis), and the NCCR TransCure.