Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structure-function analysis provides insights into the molecular working mechanisms of ligand binding and L-lactate transport.
Keywords: L-lactate transporter; SLC16 family; monocarboxylate transporter; structure; transport mechanism.
© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.