Hemodynamics of concomitant tricuspid valve procedures at LVAD implantation

J Card Surg. 2019 Dec;34(12):1511-1518. doi: 10.1111/jocs.14275. Epub 2019 Nov 6.


Background: Tricuspid regurgitation (TR) is common in patients receiving left ventricular assist device (LVAD) implantation. The current literature is conflicting regarding the effects of concomitant tricuspid valve repair (TVR) at LVAD implantation. We investigated the hemodynamic effects of concomitant TVR at LVAD implantation.

Methods: Consecutive clinically stable LVAD outpatients who underwent hemodynamic ramp testings were enrolled in this study, and they were stratified by concomitant TVR. Results of hemodynamic ramp tests were compared between the TVR group and the non-TVR group.

Results: Among 65 LVAD patients undergoing ramp tests, 34 patients had received TVR, and 31 had not. There were no significant differences in baseline characteristics between two groups except for higher degree of TR and lower pulmonary artery pulsatility index in the TVR group (P < .05 for both). Following LVAD implantation, the degree of TR improved significantly in the TVR group down to the comparable level with the non-TVR group. During ramp tests, the TVR group had steeper cardiac index slope (0.14 ± 0.12 vs 0.07 ± 0.07 L/min/m2 /step, P = .002) and higher cardiac index at set LVAD speed (2.99 ± 0.84 vs 2.52 ± 0.42 L/min/m2 , P = .007).

Conclusions: Concomitant TVR improves cardiac output and its response to LVAD speed change following LVAD implantation. Longitudinal clinical implications of such hemodynamic changes are unknown.

Keywords: heart failure; right ventricular failure; tricuspid regurgitation.

MeSH terms

  • Aged
  • Cardiac Output / physiology*
  • Exercise Test
  • Female
  • Heart Failure / physiopathology
  • Heart Failure / surgery*
  • Heart Valve Prosthesis Implantation*
  • Heart-Assist Devices*
  • Hemodynamics*
  • Humans
  • Male
  • Middle Aged
  • Tricuspid Valve / surgery*
  • Tricuspid Valve Insufficiency / physiopathology
  • Tricuspid Valve Insufficiency / surgery*