Developing a Model of Care for Home Infusions of Natalizumab for People With Multiple Sclerosis

J Infus Nurs. 2019 Nov/Dec;42(6):289-296. doi: 10.1097/NAN.0000000000000343.


Natalizumab is an effective treatment for multiple sclerosis that requires 4-weekly infusions that are usually provided in hospital outpatient clinics. In this study, a model of care (MOC), an overarching design for the provision of a health care service, was developed to permit home infusions of natalizumab. The proposed new MOC comprised 9 dimensions, in addition to the central concept of patient-centered care at home. The new MOC is responsive to patient needs and prioritizes the nurse-patient therapeutic relationship. It provides practical examples of patient-centered care to guide clinical practice for this patient population in the home setting.

MeSH terms

  • Home Infusion Therapy*
  • Humans
  • Immunologic Factors / therapeutic use*
  • Multiple Sclerosis / drug therapy*
  • Natalizumab / therapeutic use*
  • Patient-Centered Care


  • Immunologic Factors
  • Natalizumab