Pharmacokinetic Analysis of [18F]FAZA Dynamic PET Imaging Acquisitions for Highlighting Sacrum Tumor Profiles

Clin Nucl Med. 2020 Jan;45(1):e36-e38. doi: 10.1097/RLU.0000000000002813.


A patient enrolled in a clinical trial (NCT02802969) with suspicion of chordoma underwent an [F]FAZA PET/CT, a radiolabeled nitroimidazole analog of hypoxia PET imaging. The patient's images showed a different tumor profile compared to those observed in other hypoxic or nonhypoxic chordoma patients. The motivation for using [F]FAZA pharmacokinetic imaging was to compare this profile with histologically confirmed cases of chordoma. Through visual imaging and quantification of blood and tumor time-activity curves, we excluded the hypothesis that it was a chordoma, diagnosing a paraganglioma.

Publication types

  • Case Reports

MeSH terms

  • Clinical Trials as Topic
  • Female
  • Humans
  • Image Processing, Computer-Assisted*
  • Male
  • Nitroimidazoles / pharmacokinetics*
  • Positron Emission Tomography Computed Tomography*
  • Sacrum / diagnostic imaging*
  • Spinal Neoplasms / diagnostic imaging*
  • Spinal Neoplasms / metabolism*


  • Nitroimidazoles
  • fluoroazomycin arabinoside