A DNA Switch for Detecting Single Nucleotide Polymorphism within a Long DNA Sequence Under Denaturing Conditions

Wenqing Zhang; Jiuxing Li; Bruno Salena; Yingfu Li

doi:10.1002/chem.201904777

A DNA Switch for Detecting Single Nucleotide Polymorphism within a Long DNA Sequence Under Denaturing Conditions

Chemistry. 2020 Jan 13;26(3):568. doi: 10.1002/chem.201904777. Epub 2019 Nov 7.

Authors

Wenqing Zhang¹, Jiuxing Li¹, Bruno Salena², Yingfu Li¹

Affiliations

¹ M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
² Department of Medicine, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.

PMID: 31696988
DOI: 10.1002/chem.201904777

Abstract

Invited for the cover of this issue is the group of Yingfu Li at McMaster University. The image depicts a molecular switch for ultra-specific detection of DNA utilizing a guanine-quadruplex (up-right structure) resistant to denaturation by urea (ball-and-stick structures). Read the full text of the article at 10.1002/chem.201903536.

MeSH terms

DNA / chemistry
DNA / genetics*
Guanine / analysis
Guanine / chemistry*
Lithium / chemistry*
Polymorphism, Single Nucleotide / genetics*

Substances

Guanine
DNA
Lithium