NIR-II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer

doi:10.1002/adhm.201900974

. 2019 Dec;8(23):e1900974.

doi: 10.1002/adhm.201900974. Epub 2019 Nov 7.

NIR-II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer

Yongkuan Suo¹, Fengxia Wu¹, Pengfei Xu², Hui Shi¹, Tingzhong Wang³, Hongguang Liu¹, Zhen Cheng⁴

Affiliations

¹ Institute of Molecular Medicine, Joint Laboratory for Molecular Medicine, Northeastern University, Shenyang, Liaoning, 110000, China.
² Institute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining, 272000, China.
³ Department of Neurosurgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110000, China.
⁴ Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA, 94305, USA.

PMID: 31697035
DOI: 10.1002/adhm.201900974

NIR-II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer

Yongkuan Suo et al. Adv Healthc Mater. 2019 Dec.

. 2019 Dec;8(23):e1900974.

doi: 10.1002/adhm.201900974. Epub 2019 Nov 7.

Authors

Yongkuan Suo¹, Fengxia Wu¹, Pengfei Xu², Hui Shi¹, Tingzhong Wang³, Hongguang Liu¹, Zhen Cheng⁴

Affiliations

¹ Institute of Molecular Medicine, Joint Laboratory for Molecular Medicine, Northeastern University, Shenyang, Liaoning, 110000, China.
² Institute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining, 272000, China.
³ Department of Neurosurgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110000, China.
⁴ Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA, 94305, USA.

PMID: 31697035
DOI: 10.1002/adhm.201900974

Abstract

Endoscopy is a clinical gold standard to exam the interior of a hollow organ or body cavity. For the first of time, this study presents the design and construction of a fluorescent endoscopic system that harnesses the power of the second near-infrared window II (NIR-II) fluorescence imaging. An NIR-II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR-II endoscopy imaging system. Simultaneous NIR-II fluorescence and white-light (WL) imaging of VEGF is validated in an orthotopic rat colorectal cancer model. This NIR-II endoscopy system is a generalizable design, and it is compatible with the most of current clinic endoscopies. Similar hardware upgrades are expected to greatly promote the application of NIR-II fluorescent imaging in the clinic.

Keywords: colorectal cancer; endoscopy; fluorescence; molecular imaging; the second near-infrared window.

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References

1. a) R. Weissleder, U. Mahmood, Radiology 2001, 219, 316;
1. b) T. F. Massoud, S. S. Gambhir, Genes Dev. 2003, 17, 545;
1. c) T. Hussain, Q. T. Nguyen, Adv. Drug Delivery Rev. 2014, 66, 90;
1. d) J. P. B. O'Connor, E. O. Aboagye, J. E. Adams, H. J. W. L. Aerts, S. F. Barrington, A. J. Beer, R. Boellaard, S. E. Bohndiek, M. Brady, G. Brown, D. L. Buckley, T. L. Chenevert, L. P. Clarke, S. Collette, G. J. Cook, N. M. Desouza, J. C. Dickson, C. Dive, J. L. Evelhoch, C. Faivre-Finn, F. A. Gallagher, F. J. Gilbert, R. J. Gillies, V. Goh, J. R. Griffiths, A. M. Groves, S. Halligan, A. L. Harris, D. J. Hawkes, O. S. Hoekstra, E. P. Huang, B. F. Hutton, E. F. Jackson, G. C. Jayson, A. Jones, D. M. Koh, D. Lacombe, P. Lambin, N. Lassau, M. O. Leach, T. Y. Lee, E. L. Leen, J. S. Lewis, Y. Liu, M. F. Lythgoe, P. Manoharan, R. J. Maxwell, K. A. Miles, B. Morgan, S. Morris, T. Ng, A. R. Padhani, G. J. M. Parker, M. Partridge, A. P. Pathak, A. C. Peet, S. Punwani, A. R. Reynolds, S. P. Robinson, L. K. Shankar, R. A. Sharma, D. Soloviev, S. Stroobants, D. C. Sullivan, S. A. Taylor, P. S. Tofts, G. M. Tozer, M. van Herk, S. Walker-Samuel, J. Wason, K. J. Williams, P. Workman, T. E. Yankeelov, K. M. Brindle, L. M. McShane, A. Jackson, J. C. Waterton, Nat. Rev. Clin. Oncol. 2017, 14, 169.
1. a) B. Zhu, E. M. Sevick-Muraca, Br. J. Radiol. 2015, 88, 20140547;

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[1] a) R. Weissleder, U. Mahmood, Radiology 2001, 219, 316;

[2] a) R. Weissleder, U. Mahmood, Radiology 2001, 219, 316;

[3] b) T. F. Massoud, S. S. Gambhir, Genes Dev. 2003, 17, 545;

[4] b) T. F. Massoud, S. S. Gambhir, Genes Dev. 2003, 17, 545;

[5] c) T. Hussain, Q. T. Nguyen, Adv. Drug Delivery Rev. 2014, 66, 90;

[6] c) T. Hussain, Q. T. Nguyen, Adv. Drug Delivery Rev. 2014, 66, 90;

[7] d) J. P. B. O'Connor, E. O. Aboagye, J. E. Adams, H. J. W. L. Aerts, S. F. Barrington, A. J. Beer, R. Boellaard, S. E. Bohndiek, M. Brady, G. Brown, D. L. Buckley, T. L. Chenevert, L. P. Clarke, S. Collette, G. J. Cook, N. M. Desouza, J. C. Dickson, C. Dive, J. L. Evelhoch, C. Faivre-Finn, F. A. Gallagher, F. J. Gilbert, R. J. Gillies, V. Goh, J. R. Griffiths, A. M. Groves, S. Halligan, A. L. Harris, D. J. Hawkes, O. S. Hoekstra, E. P. Huang, B. F. Hutton, E. F. Jackson, G. C. Jayson, A. Jones, D. M. Koh, D. Lacombe, P. Lambin, N. Lassau, M. O. Leach, T. Y. Lee, E. L. Leen, J. S. Lewis, Y. Liu, M. F. Lythgoe, P. Manoharan, R. J. Maxwell, K. A. Miles, B. Morgan, S. Morris, T. Ng, A. R. Padhani, G. J. M. Parker, M. Partridge, A. P. Pathak, A. C. Peet, S. Punwani, A. R. Reynolds, S. P. Robinson, L. K. Shankar, R. A. Sharma, D. Soloviev, S. Stroobants, D. C. Sullivan, S. A. Taylor, P. S. Tofts, G. M. Tozer, M. van Herk, S. Walker-Samuel, J. Wason, K. J. Williams, P. Workman, T. E. Yankeelov, K. M. Brindle, L. M. McShane, A. Jackson, J. C. Waterton, Nat. Rev. Clin. Oncol. 2017, 14, 169.

[8] d) J. P. B. O'Connor, E. O. Aboagye, J. E. Adams, H. J. W. L. Aerts, S. F. Barrington, A. J. Beer, R. Boellaard, S. E. Bohndiek, M. Brady, G. Brown, D. L. Buckley, T. L. Chenevert, L. P. Clarke, S. Collette, G. J. Cook, N. M. Desouza, J. C. Dickson, C. Dive, J. L. Evelhoch, C. Faivre-Finn, F. A. Gallagher, F. J. Gilbert, R. J. Gillies, V. Goh, J. R. Griffiths, A. M. Groves, S. Halligan, A. L. Harris, D. J. Hawkes, O. S. Hoekstra, E. P. Huang, B. F. Hutton, E. F. Jackson, G. C. Jayson, A. Jones, D. M. Koh, D. Lacombe, P. Lambin, N. Lassau, M. O. Leach, T. Y. Lee, E. L. Leen, J. S. Lewis, Y. Liu, M. F. Lythgoe, P. Manoharan, R. J. Maxwell, K. A. Miles, B. Morgan, S. Morris, T. Ng, A. R. Padhani, G. J. M. Parker, M. Partridge, A. P. Pathak, A. C. Peet, S. Punwani, A. R. Reynolds, S. P. Robinson, L. K. Shankar, R. A. Sharma, D. Soloviev, S. Stroobants, D. C. Sullivan, S. A. Taylor, P. S. Tofts, G. M. Tozer, M. van Herk, S. Walker-Samuel, J. Wason, K. J. Williams, P. Workman, T. E. Yankeelov, K. M. Brindle, L. M. McShane, A. Jackson, J. C. Waterton, Nat. Rev. Clin. Oncol. 2017, 14, 169.

[9] a) B. Zhu, E. M. Sevick-Muraca, Br. J. Radiol. 2015, 88, 20140547;

[10] a) B. Zhu, E. M. Sevick-Muraca, Br. J. Radiol. 2015, 88, 20140547;

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NIR-II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer

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NIR-II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer

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