Contrast-enhanced Mammography: Current Applications and Future Directions

Radiographics. Nov-Dec 2019;39(7):1907-1920. doi: 10.1148/rg.2019190079.


Contrast-enhanced mammography (CEM) is a developing modality used for the workup and management of breast cancer. Although diagnostic imaging modalities such as mammography and US have historically been the mainstays of initial breast cancer workup, recent advances in breast MRI have allowed better disease evaluation. However, MRI is not always readily available, can be time consuming, and is contraindicated in certain patients. CEM is an alternative to US and MRI, and it can be used to obtain contrast material-enhanced information and standard mammograms simultaneously. A CEM examination is shorter than that of MRI, and the modalities have similar rates of sensitivity to detect lesions. CEM also costs less than MRI. The authors evaluate clinical uses of CEM and discuss the literature supporting these indications.©RSNA, 2019.

Publication types

  • Review
  • Webcast

MeSH terms

  • Aged
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Breast / diagnostic imaging*
  • Breast / drug effects
  • Breast Diseases / diagnostic imaging
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / drug therapy
  • Calcinosis / diagnostic imaging
  • Carcinoma, Ductal, Breast / diagnostic imaging
  • Contrast Media*
  • Diagnosis, Differential
  • Early Detection of Cancer
  • Female
  • Forecasting
  • Humans
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging / methods
  • Mammography / methods*
  • Middle Aged
  • Neoadjuvant Therapy
  • Ultrasonography, Mammary / methods


  • Antineoplastic Agents
  • Contrast Media