Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5-[18 F]fluoro-L-amino suberate

J Labelled Comp Radiopharm. 2020 Jan;63(1):6-14. doi: 10.1002/jlcr.3814. Epub 2019 Dec 8.

Abstract

System xc- (Sxc -) has emerged as a new biological target for PET studies to detect oxidative and excitotoxic stress. Notably, applications have, thus far, been limited to tumour imaging although Sxc- ) may play a major role in neurodegeneration. The synthesis procedures of tosylate precursor and its translation to Sxc - PET tracer 5[18F]fluoro-L-amino suberate by manual and automated radiosyntheses are described. A brain-PET study has been conducted to evaluate the tracer uptake into brain in healthy mice.

Keywords: System xc; brain imaging; mouse; radiosynthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport
  • Cell Line, Tumor
  • Chemistry Techniques, Synthetic
  • Fluorine Radioisotopes / chemistry*
  • Fluorine Radioisotopes / metabolism
  • Humans
  • Mice
  • Neuroimaging*
  • Positron-Emission Tomography*
  • Radiochemistry

Substances

  • Fluorine Radioisotopes
  • Fluorine-18