New quinoline alkaloid and bisabolane-type sesquiterpenoid derivatives from the deep-sea-derived fungus Aspergillus sp. SCSIO06786

Fitoterapia. 2020 Jan;140:104406. doi: 10.1016/j.fitote.2019.104406. Epub 2019 Nov 4.

Abstract

One new quinoline alkaloid (1), two new bisabolane-type sesquiterpene derivatives (2 and 3), and a new natural product (4) along with ten known compounds (514) were isolated from the deep sea-derived fungus Aspergillus sp. SCSIO06786 which cultured on solid rice medium. Three new structures were elucidated by analysis of 1D/2D NMR data and HR-ESI-MS. The absolute configurations of 2 and 3 were established by comparison of the experimental and reported ECD values. Compounds 11-13 exhibited moderate selective inhibitory activities against the tested pathogenic bacteria with MIC values among 3.13-12.5 μg/mL.

Keywords: Antibacterial; Aspergillus sp.; Deep-sea-derived fungus; Secondary metabolites.

MeSH terms

  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Aspergillus / chemistry*
  • Bacteria / drug effects
  • Geologic Sediments / microbiology
  • Indian Ocean
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Monocyclic Sesquiterpenes / isolation & purification*
  • Monocyclic Sesquiterpenes / pharmacology
  • Quinolines / isolation & purification*
  • Quinolines / pharmacology
  • Seawater / microbiology*
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Monocyclic Sesquiterpenes
  • Quinolines
  • Sesquiterpenes