Patent ductus arteriosus generates neonatal hemolytic jaundice with thrombocytopenia in Upshaw-Schulman syndrome

Blood Adv. 2019 Nov 12;3(21):3191-3195. doi: 10.1182/bloodadvances.2019000601.

Yoshihiro Fujimura^{1

2}, Bernhard Lämmle^{3

4}, Saori Tanabe⁵, Kazuya Sakai², Toshiyuki Kimura⁵, Koichi Kokame⁶, Toshiyuki Miyata^{6

7}, Yukihiro Takahashi¹, Shigeki Taniguchi⁸, Masanori Matsumoto²

¹ Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan.
² Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan.
³ Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁴ Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.
⁵ Department of Pediatrics, Nihonkai General Hospital, Sakata, Japan.
⁶ Department of Molecular Pathogenesis and.
⁷ Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan; and.
⁸ Department of Thoracic and Cardiovascular Surgery, Nara Medical University, Kashihara, Japan.

Abstract

One third of patients with USS have a neonatal episode of severe hemolytic jaundice with thrombocytopenia induced by an unknown trigger.
A USS patient with persisting PDA and recurrent neonatal hemolysis/thrombocytopenia suggests blood flow through the PDA as trigger.