Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer

Trends Biochem Sci. 2019 Dec;44(12):991-993. doi: 10.1016/j.tibs.2019.10.007. Epub 2019 Nov 4.


Senescence is engaged in response to oncogenes to suppress proliferation. Cancers rewire metabolism to facilitate proliferation; however, it is not well appreciated how this enables senescence bypass. Recent work by Buj et al. demonstrates that loss of the tumor suppressor p16 engages a mTORC1-dependent increase in nucleotide pools to override senescence.

Keywords: RPIA; mTORC1; nucleotide metabolism; p16; pentose phosphate pathway.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cellular Senescence*
  • Humans
  • Mechanistic Target of Rapamycin Complex 1
  • Neoplasms / genetics*
  • Nucleotides
  • Oncogenes


  • Nucleotides
  • Mechanistic Target of Rapamycin Complex 1