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Review
. 2019 Nov 7;35(11):178.
doi: 10.1007/s11274-019-2739-1.

Metabolomic Studies of Pseudomonas Aeruginosa

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Free PMC article
Review

Metabolomic Studies of Pseudomonas Aeruginosa

Karolina Anna Mielko et al. World J Microbiol Biotechnol. .
Free PMC article

Abstract

Pseudomonas aeruginosa is a common, Gram-negative environmental organism. It can be a significant pathogenic factor of severe infections in humans, especially in cystic fibrosis patients. Due to its natural resistance to antibiotics and the ability to form biofilms, infection with this pathogen can cause severe therapeutic problems. In recent years, metabolomic studies of P. aeruginosa have been performed. Therefore, in this review, we discussed recent achievements in the use of metabolomics methods in bacterial identification, differentiation, the interconnection between genome and metabolome, the influence of external factors on the bacterial metabolome and identification of new metabolites produced by P. aeruginosa. All of these studies may provide valuable information about metabolic pathways leading to an understanding of the adaptations of bacterial strains to a host environment, which can lead to new drug development and/or elaboration of new treatment and diagnostics strategies for Pseudomonas.

Keywords: Cystic fibrosis; Metabolomic experiment; Metabolomics; Pseudomonas aeruginosa; Strain identification.

Conflict of interest statement

All authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Metabolomic studies of Pseudomonas aeruginosa
Fig. 2
Fig. 2
Diagram of metabolomic experiment

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