Anti‑gouty arthritis and anti‑hyperuricemia properties of celery seed extracts in rodent models

Mol Med Rep. 2019 Nov;20(5):4623-4633. doi: 10.3892/mmr.2019.10708. Epub 2019 Sep 26.


Gout is a type of serious arthritis that is caused by hyperuricemia. Celery is an umbelliferous plant that was shown to exhibit anti‑inflammatory activity in rodent. The present study aimed to investigate the effects and potential preliminary mechanisms of celery seed aqueous extract (CSAE) and celery seed oil extract (CSOL) for gout treatment. The components of CSAE and CSOL were systematically analyzed. In mice with hyperuricemia induced by potassium oxonate and yeast extract, CSAE and CSOL treatment reduced the serum levels of uric acid and xanthine oxidase. In addition, CSAE and CSOL reduced the levels of reactive oxygen species and increased the serum levels of superoxide dismutase and glutathione peroxidase in mouse serum. In rats with acute gouty arthritis induced by intra‑articular injection of monosodium urate crystals, CSAE and CSOL treatment alleviated the swelling of the ankle joints and reduced inflammatory cell infiltration around the ankle joints. In addition, CSAE and CSOL reduced the levels of interleukin (IL)‑1β and tumor necrosis factor α and increased the levels of IL‑10. The results of the present study suggested that celery seed extracts may have anti‑gout properties, partially through anti‑inflammatory and antioxidative effects.

MeSH terms

  • Animals
  • Apium / chemistry*
  • Arthritis, Gouty / chemically induced
  • Arthritis, Gouty / drug therapy*
  • Arthritis, Gouty / metabolism
  • Arthritis, Gouty / pathology
  • Hyperuricemia / chemically induced
  • Hyperuricemia / drug therapy*
  • Hyperuricemia / metabolism
  • Hyperuricemia / pathology
  • Interleukin-10 / metabolism
  • Interleukin-1beta / metabolism
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Seeds / chemistry*


  • IL10 protein, mouse
  • IL1B protein, mouse
  • Interleukin-1beta
  • Plant Extracts
  • Interleukin-10