Protection against noise trauma by pre-exposure to a low level acoustic stimulus

Hear Res. 1988 Jul 15;34(2):197-200. doi: 10.1016/0378-5955(88)90107-4.


Guinea pigs were pre-exposed to a low level acoustic stimulus prior to exposure to a stimulus known to yield a permanent threshold shift. This pre-treatment resulted in: 1) approximately a 20 dB reduction in the threshold shift relative to animals not pre-exposed, and 2) complete recovery from the threshold shift after 2 months.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation*
  • Animals
  • Auditory Fatigue / physiology
  • Auditory Threshold / physiology
  • Evoked Potentials, Auditory
  • Guinea Pigs
  • Hearing Loss, Noise-Induced / physiopathology*
  • Hearing Loss, Noise-Induced / prevention & control