Exercise, Dopamine, and Cognition in Older Age

Trends Cogn Sci. 2019 Dec;23(12):986-988. doi: 10.1016/j.tics.2019.10.006. Epub 2019 Nov 5.


Jonasson et al. investigated whether individual differences in human dopamine receptors (D2R) were related to cognitive performance before and after a 6-month aerobic exercise intervention (compared with active control). While D2R decreased (perhaps counterintuitively) with exercise, there was no relationship between D2R and working memory at baseline or following exercise.

Keywords: aging; fitness; working memory.

Publication types

  • Comment

MeSH terms

  • Aged
  • Cognition
  • Dopamine*
  • Exercise
  • Humans
  • Physical Fitness
  • Resistance Training*


  • Dopamine