Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma

Anticancer Res. 2019 Nov;39(11):6067-6071. doi: 10.21873/anticanres.13814.


Background/aim: Thrombin plays significant roles in various types of cancer. However, the expression levels of prothrombin, the thrombin precursor, in cancer remain unclear. Variants of the 3'end of the prothrombin gene lead to increased prothrombin expression. This study aimed to analyze prothrombin 3'end gene variants in colon tumor and adjacent normal tissue samples.

Materials and methods: The study group consisted of 93 patients suffering from colon adenocarcinoma. The 3'end of the prothrombin gene was analyzed by DNA sequencing.

Results: Three variants, all previously associated with increased prothrombin expression were detected. Frequency of the FII 19911G allele was 46.77% and 47.85% in tumor and normal tissue, respectively. For the FII 20210A allele, the detected frequencies were 2.15% and 1.61%, respectively. The frequency of the FII c.1824T allele was 0.54% in both tissues. Four patients showed different genotypes in tumor and normal tissue.

Conclusion: Prothrombin 3' end gene variants may play a role in colorectal cancer.

Keywords: 3’end gene variants; Colon adenocarcinoma; normal adjacent tissue; prothrombin; tumor.

MeSH terms

  • 3' Untranslated Regions / genetics*
  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / genetics*
  • Case-Control Studies
  • Colonic Neoplasms / genetics*
  • Colonic Neoplasms / pathology
  • Female
  • Follow-Up Studies
  • Gene Expression Regulation, Neoplastic*
  • Genetic Variation*
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Prothrombin / genetics*


  • 3' Untranslated Regions
  • Biomarkers, Tumor
  • Prothrombin