EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation

Protein Cell. 2020 Feb;11(2):144-149. doi: 10.1007/s13238-019-00668-8.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Dipeptides / pharmacology
  • ErbB Receptors / antagonists & inhibitors
  • ErbB Receptors / metabolism
  • HEK293 Cells
  • Humans
  • Hydroxamic Acids / pharmacology
  • Lipopolysaccharides / antagonists & inhibitors
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects
  • Macrophages / metabolism*
  • Phosphorylation / drug effects
  • Quinazolines / pharmacology
  • Signal Transduction / drug effects
  • Surface Properties
  • Toll-Like Receptor 4 / genetics
  • Toll-Like Receptor 4 / metabolism*
  • rab5 GTP-Binding Proteins / antagonists & inhibitors
  • rab5 GTP-Binding Proteins / metabolism*

Substances

  • Dipeptides
  • Hydroxamic Acids
  • Lipopolysaccharides
  • N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide
  • PD168393
  • Quinazolines
  • TLR4 protein, human
  • Toll-Like Receptor 4
  • EGFR protein, human
  • ErbB Receptors
  • RAB5C protein, human
  • rab5 GTP-Binding Proteins