Characterization of longitudinal wheeze phenotypes from infancy to adolescence in Project Viva, a prebirth cohort study

Joanne E Sordillo; Brent A Coull; Sheryl L Rifas-Shiman; Ann Chen Wu; Sharon M Lutz; Marie-France Hivert; Emily Oken; Diane R Gold

doi:10.1016/j.jaci.2019.10.026

Characterization of longitudinal wheeze phenotypes from infancy to adolescence in Project Viva, a prebirth cohort study

J Allergy Clin Immunol. 2020 Feb;145(2):716-719.e8. doi: 10.1016/j.jaci.2019.10.026. Epub 2019 Nov 6.

Authors

Joanne E Sordillo¹, Brent A Coull², Sheryl L Rifas-Shiman¹, Ann Chen Wu³, Sharon M Lutz³, Marie-France Hivert¹, Emily Oken¹, Diane R Gold⁴

Affiliations

¹ Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass.
² Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Mass.
³ Precision Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass.
⁴ Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address: redrg@channing.harvard.edu.

Abstract

Using data from infancy to adolescence, our analysis of longitudinal wheeze phenotypes allowed us to visualize four longitudinal wheeze trajectories (never/infrequent wheeze, mid-childhood onset wheeze, early transient wheeze, and persistent wheeze).

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Adolescent
Child
Child, Preschool
Cohort Studies
Female
Humans
Infant
Infant, Newborn
Longitudinal Studies
Male
Phenotype
Respiratory Sounds* / genetics

Abstract

Publication types

MeSH terms

Grants and funding