A new compound Trichomicin exerts antitumor activity through STAT3 signaling inhibition

Biomed Pharmacother. 2020 Jan;121:109608. doi: 10.1016/j.biopha.2019.109608. Epub 2019 Nov 7.


Trichomicin, a novel small-molecule compound isolated from the fungus Trichoderma harzianum and identified as new structure compound, exhibited antitumor activities in various human cancer cell lines and reversed drug resistance activity in the multidrug-resistant cancer cell line KBV. The underlying cellular and molecular mechanism was illuminated. Trichomicin can significantly induce cancer cell apoptosis and reduced IL-6 expression and phosphorylation of STAT3 were found in response to Trichomicin treatment. The blockade of IL-6 mediated JAK-STAT3 signaling pathway by Trichomicin was confirmed using reporter gene system. As a promising antitumor-activity compound, Trichomicin is presented in this study.

Keywords: Antitumor; Compound; JAK/STAT3; Nature product; Trichomicin.

MeSH terms

  • Animals
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / toxicity
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Drug Resistance, Neoplasm
  • Humans
  • Hypocreales / chemistry*
  • Interleukin-6 / antagonists & inhibitors
  • Mice
  • Phosphorylation
  • STAT3 Transcription Factor / antagonists & inhibitors*
  • STAT3 Transcription Factor / physiology
  • Signal Transduction / drug effects


  • Antineoplastic Agents
  • Interleukin-6
  • STAT3 Transcription Factor

Supplementary concepts

  • Trichoderma harzianum