Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes

Valery N Kozhevnikov; Michael E Deary; Theodora Mantso; Mihalis I Panayiotidis; Mark T Sims

doi:10.1039/c9cc06828g

Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes

Chem Commun (Camb). 2019 Nov 26;55(95):14283-14286. doi: 10.1039/c9cc06828g.

Authors

Valery N Kozhevnikov¹, Michael E Deary, Theodora Mantso, Mihalis I Panayiotidis, Mark T Sims

Affiliation

¹ Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. valery.kozhevnikov@northumbria.ac.uk.

PMID: 31709444
DOI: 10.1039/c9cc06828g

Abstract

In this paper we describe unprecedented Ir(iii) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(iii) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M-1 s-1, the record value to date for a triazine-BCN reaction.