White Blood Cell Counts, Lymphocyte Subsets, and Incident Diabetes Mellitus in Women Living With and Without HIV

AIDS Res Hum Retroviruses. 2020 Feb;36(2):131-133. doi: 10.1089/AID.2019.0174. Epub 2019 Dec 17.


Diabetes mellitus (DM) is associated with expansion of proinflammatory lymphocyte subsets. We investigated the relationship of total white blood cell (WBC) count and lymphocyte subsets with incident DM in the Women's Interagency HIV Study (WIHS). Higher CD4 and CD8 T cell counts, lymphocyte count, and total WBC count were associated with incident DM among both women with and without HIV, although the association of CD8 was not statistically significant among women without HIV.

Keywords: CD4; CD8; HIV-1; diabetes mellitus; lymphocyte; white blood cell; women.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • CD4 Lymphocyte Count
  • CD4-CD8 Ratio
  • CD8-Positive T-Lymphocytes / immunology
  • Diabetes Complications / epidemiology
  • Diabetes Complications / immunology
  • Diabetes Complications / virology*
  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / immunology*
  • Female
  • HIV Infections / complications*
  • HIV Infections / epidemiology
  • HIV Infections / immunology*
  • Humans
  • Leukocyte Count
  • Lymphocyte Subsets / immunology*
  • Middle Aged
  • Prospective Studies
  • United States / epidemiology