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. 2020 Feb;35(2):349-354.
doi: 10.1002/mds.27914. Epub 2019 Nov 11.

Retina thickness as a marker of neurodegeneration in prodromal lewy body disease

Jee-Young Lee  1 , Jeeyun Ahn  2 , Sohee Oh  3 , Joo Young Shin  2 , Yu Kyeong Kim  4 , Hyunwoo Nam  1 , Beomseok Jeon  5
Affiliations

Retina thickness as a marker of neurodegeneration in prodromal lewy body disease

Jee-Young Lee et al. Mov Disord. 2020 Feb.

Abstract

Objectives: We investigated retinal change and its relationship with neurodegeneration markers in a prodromal Parkinson cohort.

Methods: A total of 30 patients with idiopathic rapid eye movement sleep behavior disorder were recruited. Participants underwent olfactory testing, macular optical coherence tomography, microperimetry, contrast sensitivity test, and brain N-(3-[18 F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane positron emission tomography. We measured the ganglion cell complex thicknesses and investigated its correlation with olfactory function and striatal dopamine transporter availability. A linear mixed-effect model was applied with adjustment for multiple comparisons.

Results: The parafoveal ganglion-cell-complex thickness in this cohort lay between our healthy control and drug-naïve Parkinson's disease group data. Idiopathic rapid eye movement sleep behavior disorder patients also had contrast sensitivity impairment as in Parkinson's disease with a nonsignificant change in macular sensitivities. Macular ganglion cell complex thickness correlated with olfactory scores and with striatal dopamine transporter availabilities.

Conclusions: Macular ganglion cell complex thinning may be a marker of neurodegeneration in prodromal Parkinson's disease. © 2019 International Parkinson and Movement Disorder Society.

Keywords: Parkinson's disease; biomarker; idiopathic rapid eye movement sleep behavior disorder; optical coherence tomography; retina.

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