Direct Access to Allenylphosphine Oxides via a Metal Free Coupling of Propargylic Substrates with P(O)H Compounds

Chun-Hua Yang; Huihui Fan; Huimin Li; Shenyin Hou; Xiangkun Sun; Donghao Luo; Yinchao Zhang; Zhantao Yang; Junbiao Chang

doi:10.1021/acs.orglett.9b03645

Direct Access to Allenylphosphine Oxides via a Metal Free Coupling of Propargylic Substrates with P(O)H Compounds

Org Lett. 2019 Dec 6;21(23):9438-9441. doi: 10.1021/acs.orglett.9b03645. Epub 2019 Nov 11.

Authors

Chun-Hua Yang¹, Huihui Fan¹, Huimin Li¹, Shenyin Hou¹, Xiangkun Sun¹, Donghao Luo¹, Yinchao Zhang¹, Zhantao Yang^{1

2}, Junbiao Chang²

Affiliations

¹ Henan Key Laboratory of New Optoelectronic Functional Materials, College of Chemistry and Chemical Engineering , Anyang Normal University , 436 Xian'ge Road , Anyang 455000 , P. R. China.
² School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , Henan 450001 , P. R. China.

PMID: 31710501
DOI: 10.1021/acs.orglett.9b03645

Abstract

A direct and convenient approach for the coupling of propargylic substrates with diphenylphosphine oxide in the presence of Tf₂O and 2,6-lutidine has been developed. The method provides a general approach for the construction of attractive allenylphosphoryl skeletons with high atom and step economy under metal free conditions.