Paroxismal non-kinesigenic dyskinesia and hemidystonia associated with silent celiac disease

Clin Neurol Neurosurg. 2020 Jan;188:105586. doi: 10.1016/j.clineuro.2019.105586. Epub 2019 Nov 4.


Paroxismal non-kinesigenic dyskinesia (PNKD) is a rare movement disorder manifesting as choreatic/dystonic movements, usually lasting from minutes to up to 4 h, with perserved consciousness during attacks. Primary PNKD are idiopathic or genetic disorders while secondary PNKD are associated with various neurologic and medical conditions. We present a case with PNKD and right sided hemidystonia in association with celiac disease, responsive to gluten-free diet, not previously reported in available literature. In conclusion, diagnostic tests for celiac disease should be a part of etiological investigations in patients with otherwise unexplained movement disorders including PKND. Gluten free diet could produce a favorable clinical response in those patients.

Keywords: Celiac disease; Clinical presentation; PNKD (paroxysmal non-kinesigenic dyskinesia).