Predictive role of laboratory markers and clinical features for recurrent Henoch-Schönlein Purpura in childhood: A study from Turkey

Mod Rheumatol. 2020 Nov;30(6):1047-1052. doi: 10.1080/14397595.2019.1690966. Epub 2020 Feb 3.

Abstract

Objectives: Henoch Schönlein Purpura is the most common systemic vasculitis of the childhood. The objective of this study was to evaluate whether there is a clinical significance of laboratory parameters and clinical features on the prediction of the recurrent Henoch Schönlein Purpura in children.Methods: For recurrent Henoch Schönlein Purpura, several laboratory results and clinical features were examined to identify the predictor factors via the logistic regression model in 99 children with Henoch Schönlein Purpura. A p-value of <.05 was considered significant. The patients were divided into two groups as the first attack and the recurrent.Results: The demographic features and laboratory results were not found statistically significant between the two groups (p > .05). The multiple logistic regression model showed that the risk of recurrent Henoch Schönlein Purpura increased 17.2-fold in children with Henoch Schönlein Purpura affected by the four systems including skin, joint, kidney and gastrointestinal system [Odds Ratio (OR) 17.2, 95% CI 1.4-12; p < .001].Conclusion: In our inpatient population, the laboratory characteristics were detected not to be a factor for the prediction of recurrence. However, the four systems including skin, joint, kidney and gastrointestinal involvement may be used as a predictive factor for recurrent HSP.

Keywords: Child; Henoch-Schonlein vasculitis; prediction of recurrency; recurrence.

MeSH terms

  • Adolescent
  • Arthritis / epidemiology*
  • Child
  • Child, Preschool
  • Female
  • Gastrointestinal Diseases / epidemiology*
  • Humans
  • IgA Vasculitis / complications*
  • IgA Vasculitis / epidemiology
  • IgA Vasculitis / pathology
  • Kidney Diseases / epidemiology*
  • Male
  • Recurrence
  • Skin Diseases / epidemiology*