Association of N6-methyladenosine with viruses and related diseases

doi:10.1186/s12985-019-1236-3

Review

. 2019 Nov 11;16(1):133.

doi: 10.1186/s12985-019-1236-3.

Association of N6-methyladenosine with viruses and related diseases

Fang Wu^{1

2}, Wenzhao Cheng^{3

4}, Feiyuan Zhao^{1

2}, Mingqing Tang^{1

2

5}, Yong Diao², Ruian Xu^{6

7

8}

Affiliations

¹ Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University, Xiamen, China.
² School of Medicine, Huaqiao University, Xiamen, China.
³ Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University, Xiamen, China. wenzhao.cheng@hotmail.com.
⁴ Stem Cell Laboratory, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China. wenzhao.cheng@hotmail.com.
⁵ Fujian Provincial Key Laboratory of Molecular Medicine & Fujian Provincial Key Laboratory of Precision Medicine and Molecular Detection in Universities, Xiamen, China.
⁶ Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University, Xiamen, China. ruianxu@hqu.edu.cn.
⁷ School of Medicine, Huaqiao University, Xiamen, China. ruianxu@hqu.edu.cn.
⁸ Fujian Provincial Key Laboratory of Molecular Medicine & Fujian Provincial Key Laboratory of Precision Medicine and Molecular Detection in Universities, Xiamen, China. ruianxu@hqu.edu.cn.

PMID: 31711514
PMCID: PMC6849232
DOI: 10.1186/s12985-019-1236-3

Free PMC article

Review

Association of N6-methyladenosine with viruses and related diseases

Fang Wu et al. Virol J. 2019.

Free PMC article

. 2019 Nov 11;16(1):133.

doi: 10.1186/s12985-019-1236-3.

Authors

Fang Wu^{1

2}, Wenzhao Cheng^{3

4}, Feiyuan Zhao^{1

2}, Mingqing Tang^{1

2

5}, Yong Diao², Ruian Xu^{6

7

8}

Affiliations

¹ Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University, Xiamen, China.
² School of Medicine, Huaqiao University, Xiamen, China.
³ Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University, Xiamen, China. wenzhao.cheng@hotmail.com.
⁴ Stem Cell Laboratory, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China. wenzhao.cheng@hotmail.com.
⁵ Fujian Provincial Key Laboratory of Molecular Medicine & Fujian Provincial Key Laboratory of Precision Medicine and Molecular Detection in Universities, Xiamen, China.
⁶ Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University, Xiamen, China. ruianxu@hqu.edu.cn.
⁷ School of Medicine, Huaqiao University, Xiamen, China. ruianxu@hqu.edu.cn.
⁸ Fujian Provincial Key Laboratory of Molecular Medicine & Fujian Provincial Key Laboratory of Precision Medicine and Molecular Detection in Universities, Xiamen, China. ruianxu@hqu.edu.cn.

PMID: 31711514
PMCID: PMC6849232
DOI: 10.1186/s12985-019-1236-3

Abstract

Background: N6-methyladenosine (m6A) modification is the most prevalent internal modification of eukaryotic mRNA modulating gene expression. m6A modification is a dynamic reversible process regulated by three protein groups: methyltransferases (writers), demethylases (erasers), and m6A-binding proteins (readers). m6A modification is involved in all phases of RNA metabolism, including RNA folding, stability, splicing, nuclear exporting, translational modulation and degradation.

Main body: In recent years, numerous studies have reported that abnormal m6A modification causes aberrant expression of important viral genes. Herein, we review the role of m6A in viral lifecycle and its contribution to the pathogenesis of human diseases. Particularly, we focus on the viruses associated with human diseases such as HIV-1, IAV, HBV, HCV, EBV and many others.

Conclusions: A better understanding of m6A-virus relationship would provide new insights into the viral replication process and pathogenesis of human diseases caused by viruses. In addition, exploration of the role of m6A in disease-causing viruses will reveal novel approaches for the treatment of such diseases.

Keywords: Demethylases; Methyltransferases; N6-methyladenosine (m6A); Viral diseases; m6A-binding proteins.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

**Fig. 1**
A schematic model that illustrates the roles and regulation of m6A modification. m6A modification is regulated by “writers” “erasers” and “readers”. Writers and erasers are mainly located in the nucleus, where they modulate mRNAs splicing and nuclear export. YTHDC1 and HNRP2AB1 as nuclear readers also play a vital role in nuclear export. In the cytoplasm, YTHDF2 promotes degradation of mRNA; whereas YTHDF1/3, YTHDC2 and eIF3 participate in translation

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References

1. Kennedy EM, Bogerd HP, Kornepati AV, Kang D, Ghoshal D, Marshall JB, Poling BC, Tsai K, Gokhale NS, Horner SM, et al. Posttranscriptional m(6)a editing of HIV-1 mRNAs enhances viral gene expression. Cell Host Microbe. 2016;19:675–685. doi: 10.1016/j.chom.2016.04.002. - DOI - PMC - PubMed
1. Boccaletto P, Machnicka MA, Purta E, Piatkowski P, Baginski B, Wirecki TK, de Crecy-Lagard V, Ross R, Limbach PA, Kotter A, et al. MODOMICS: a database of RNA modification pathways. 2017 update. Nucleic Acids Res. 2018;46:D303–D307. doi: 10.1093/nar/gkx1030. - DOI - PMC - PubMed
1. Cantara WA, Crain PF, Rozenski J, McCloskey JA, Harris KA, Zhang X, Vendeix FA, Fabris D, Agris PF. The RNA Modification Database, RNAMDB: 2011 update. Nucleic Acids Res. 2011;39:D195–D201. doi: 10.1093/nar/gkq1028. - DOI - PMC - PubMed
1. Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci U S A. 1974;71:3971–3975. doi: 10.1073/pnas.71.10.3971. - DOI - PMC - PubMed
1. Meyer KD, Jaffrey SR. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat Rev Mol Cell Biol. 2014;15:313–326. doi: 10.1038/nrm3785. - DOI - PMC - PubMed

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[1] Kennedy EM, Bogerd HP, Kornepati AV, Kang D, Ghoshal D, Marshall JB, Poling BC, Tsai K, Gokhale NS, Horner SM, et al. Posttranscriptional m(6)a editing of HIV-1 mRNAs enhances viral gene expression. Cell Host Microbe. 2016;19:675–685. doi: 10.1016/j.chom.2016.04.002. - DOI - PMC - PubMed

[2] Kennedy EM, Bogerd HP, Kornepati AV, Kang D, Ghoshal D, Marshall JB, Poling BC, Tsai K, Gokhale NS, Horner SM, et al. Posttranscriptional m(6)a editing of HIV-1 mRNAs enhances viral gene expression. Cell Host Microbe. 2016;19:675–685. doi: 10.1016/j.chom.2016.04.002. - DOI - PMC - PubMed

[3] Boccaletto P, Machnicka MA, Purta E, Piatkowski P, Baginski B, Wirecki TK, de Crecy-Lagard V, Ross R, Limbach PA, Kotter A, et al. MODOMICS: a database of RNA modification pathways. 2017 update. Nucleic Acids Res. 2018;46:D303–D307. doi: 10.1093/nar/gkx1030. - DOI - PMC - PubMed

[4] Boccaletto P, Machnicka MA, Purta E, Piatkowski P, Baginski B, Wirecki TK, de Crecy-Lagard V, Ross R, Limbach PA, Kotter A, et al. MODOMICS: a database of RNA modification pathways. 2017 update. Nucleic Acids Res. 2018;46:D303–D307. doi: 10.1093/nar/gkx1030. - DOI - PMC - PubMed

[5] Cantara WA, Crain PF, Rozenski J, McCloskey JA, Harris KA, Zhang X, Vendeix FA, Fabris D, Agris PF. The RNA Modification Database, RNAMDB: 2011 update. Nucleic Acids Res. 2011;39:D195–D201. doi: 10.1093/nar/gkq1028. - DOI - PMC - PubMed

[6] Cantara WA, Crain PF, Rozenski J, McCloskey JA, Harris KA, Zhang X, Vendeix FA, Fabris D, Agris PF. The RNA Modification Database, RNAMDB: 2011 update. Nucleic Acids Res. 2011;39:D195–D201. doi: 10.1093/nar/gkq1028. - DOI - PMC - PubMed

[7] Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci U S A. 1974;71:3971–3975. doi: 10.1073/pnas.71.10.3971. - DOI - PMC - PubMed

[8] Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci U S A. 1974;71:3971–3975. doi: 10.1073/pnas.71.10.3971. - DOI - PMC - PubMed

[9] Meyer KD, Jaffrey SR. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat Rev Mol Cell Biol. 2014;15:313–326. doi: 10.1038/nrm3785. - DOI - PMC - PubMed

[10] Meyer KD, Jaffrey SR. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat Rev Mol Cell Biol. 2014;15:313–326. doi: 10.1038/nrm3785. - DOI - PMC - PubMed

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Association of N6-methyladenosine with viruses and related diseases

Affiliations

Association of N6-methyladenosine with viruses and related diseases

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Abstract

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