Efficacy of Bacteriophages in a Staphylococcus aureus Nondiabetic or Diabetic Foot Infection Murine Model

Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01870-19. doi: 10.1128/AAC.01870-19. Print 2020 Jan 27.


This study investigated the in vivo efficacy of three bacteriophages combined compared with linezolid in two mouse models (nondiabetic and diabetic) of Staphylococcus aureus foot infection. In both models, a single injection of bacteriophages in the hindpaw showed significant antibacterial efficacy. Linezolid was as effective as bacteriophages in nondiabetic animals but ineffective in diabetic animals. These findings further support preclinical and clinical studies for the development of phage therapy.

Keywords: Staphylococcus aureus; bacteriophages; diabetic foot infection; preclinical drug studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteriophages / physiology*
  • Diabetic Foot / microbiology
  • Diabetic Foot / therapy*
  • Disease Models, Animal
  • Female
  • Linezolid / therapeutic use*
  • Mice
  • Mice, Inbred BALB C
  • Phage Therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / therapy*
  • Staphylococcus aureus / virology*


  • Anti-Bacterial Agents
  • Linezolid