An integrative framework for perceptual disturbances in psychosis

Nat Rev Neurosci. 2019 Dec;20(12):763-778. doi: 10.1038/s41583-019-0234-1.


Perceptual disturbances in psychosis, such as auditory verbal hallucinations, are associated with increased baseline activity in the associative auditory cortex and increased dopamine transmission in the associative striatum. Perceptual disturbances are also associated with perceptual biases that suggest increased reliance on prior expectations. We review theoretical models of perceptual inference and key supporting physiological evidence, as well as the anatomy of associative cortico-striatal loops that may be relevant to auditory perceptual inference. Integrating recent findings, we outline a working framework that bridges neurobiology and the phenomenology of perceptual disturbances via theoretical models of perceptual inference.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cerebral Cortex / metabolism*
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism*
  • Hallucinations / metabolism*
  • Hallucinations / psychology
  • Humans
  • Nerve Net / metabolism*
  • Psychotic Disorders / metabolism*
  • Psychotic Disorders / psychology


  • Dopamine