Objective: To investigate the prevalence and risk factors of Blastocystis hominis infections among patients with HIV/AIDS in Fuyang City, Anhui Province.
Methods: A cross-sectional study was conducted in Fuyang City, Anhui Province in 2016. The demographic and socioeconomic status, and the lifestyle and production style were collected using a questionnaire survey. B. hominis DNA was detected in subjects'stool samples using a PCR assay, and the CD4+ T lymphocyte count and HIV viral load were measured in the subjects' blood samples. The risk factors of B. hominis infections among patients with HIV/AIDS were identified using univariate and multivariate logistic regression analyses.
Results: A total of 398 HIV/AIDS patients were enrolled in this study, with a mean age of 49.3 years, a mean body weight of 55.9 kg and a mean height of 164.4 cm. The prevalence of B. hominis infection was 6.78% in the study subjects, and no gender- (χ2 = 1.589, P = 0.207), education level- (χ2 =0.508, P = 0.776), marital status- (χ2 = 0.419, P = 0.811) or occupation-specific prevalence (χ2 = 2.744, P = 0.615) was detected. Among the patients with HIV/AIDS, there were no significant differences in the age (t = 0.370, P = 0.712), height (t = 1.587, P =0.113), body weight (t = 0.516, P = 0.606), CD4+ T lymphocyte count (t = 1.187, P = 0.230) or HIV viral load (t = 0.193, P =0.496) between B. hominis-infected and uninfected individuals. Dinking non-tap water [OR = 6.554, 95% CI: (1.876 to 22.903)] and keeping dogs [OR = 5.895, 95% CI: (2.017 to 17.225)] were identified as risk factors for B. hominis infection in patients with HIV/AIDS.
Conclusions: The prevalence of B. hominis infection is high in HIV/AIDS patients, and drinking non-tap water and keeping dogs are risk factors for B. hominis infection among HIV/AIDS patients.
［摘要］ 目的 调查安徽省阜阳市 HIV/AIDS 患者人芽囊原虫感染情况及其危险因素。方法 2016年采用横断面调查 方法对安徽省阜阳市 HIV/AIDS 感染者进行问卷调查, 收集调查对象一般人口学信息、社会经济状况、生产生活方式信 息。采集调查对象粪便, 通过PCR方法检测粪便基因组中人芽囊原虫DNA以判定感染状况; 同时采集调查对象血液, 检 测其中CD4+T淋巴细胞数量和 HIV 病毒载量。采用单因素分析和多因素logistic回归分析对 HIV/AIDS 患者人芽囊原虫 感染的危险因素进行分析。结果 本研究共招募398名 HIV/AIDS 病例, 平均年龄为49.3岁、平均体重为55.9 kg、平均身 高为164.4 cm。人芽囊原虫感染率为6.78%, 不同性别 (χ2 = 1.589, P = 0.207) 、受教育程度 (χ2 = 0.508, P = 0.776) 、婚姻 (χ2 = 0.419, P = 0.811) 和职业 (χ2 = 2.744, P = 0.615) 患者感染率差异均无统计学意义。人芽囊原虫感染者和非感染者年 龄 (t = 0.370, P = 0.712) 、身高 (t = 1.587, P = 0.113) 、体重 (t = 0.516, P = 0.606) 、CD4+ T 淋巴细胞数量 (t = 1.187, P = 0.230) 和 HIV 病毒载量 (t = 0.193, P = 0.496) 差异均无统计学意义。饮用非自来水[OR = 6.554, 95% CI： (1.876, 22.903) ] 和养狗[OR = 5.895, 95% CI： (2.017, 17.225) ]是 HIV/AIDS 患者感染人芽囊原虫的危险因素。结论 安徽省阜阳市 HIV/AIDS 患者人芽囊原虫感染率较高, 饮用非自来水和养狗是该人群人芽囊原虫感染的危险因素。.
Keywords: Blastocystis hominis; Co-infection; Fuyang City; HIV/AIDS; Risk factor.