Retrospective evaluation of the clinical course and outcome following grape or raisin ingestion in dogs (2005-2014): 139 cases

J Vet Emerg Crit Care (San Antonio). 2020 Jan;30(1):60-65. doi: 10.1111/vec.12905. Epub 2019 Nov 12.


Objective: To describe the prevalence of acute kidney injury (AKI), clinical course, decontamination procedures, and outcome in dogs following grape or raisin ingestion.

Design: Retrospective case series from 2005 to 2014.

Setting: Three university veterinary teaching hospitals.

Animals: One hundred thirty-nine client-owned dogs with known grape or raisin ingestion.

Measurements and main results: Among dogs with biochemical data, the prevalence of AKI was 6.7% (8/120). The prevalence of AKI in the early presentation (3/67) and late (5/53) presentation groups were 4.5% and 9%, respectively. The prevalence of AKI was not significantly different between groups (P = 0.27). Four dogs (3.3%) were azotemic at presentation and 4 dogs (3.3%) had increases in creatinine of ≥26.5 µmol/L (0.3 mg/dL) at recheck (3 from the early and 1 from the late group). Vomiting was the most common clinical sign (18/139). One hundred twenty-two dogs (88%) underwent gastrointestinal decontamination and significantly more dogs in the early group were decontaminated (P < 0.0001). Two dogs received continuous renal replacement therapy. One hundred thirty-eight dogs survived and 1 died.

Conclusions: The prevalence of AKI and mortality was low in dogs with confirmed grape or raisin ingestion. Due to the retrospective nature of the study, conclusions about the utility of gastrointestinal decontamination and other therapies cannot be made.

Keywords: acute renal failure; azotemia; canine; renal function; toxicology-general.

Publication types

  • Multicenter Study

MeSH terms

  • Acute Kidney Injury / complications
  • Acute Kidney Injury / epidemiology
  • Acute Kidney Injury / veterinary*
  • Animals
  • Dog Diseases / blood
  • Dog Diseases / epidemiology*
  • Dogs
  • Female
  • Male
  • Poisoning / complications
  • Poisoning / veterinary
  • Prevalence
  • Retrospective Studies
  • United States / epidemiology
  • Vitis / poisoning*