The influence of clinical variables on the risk of developing chronic conditions in ICU survivors

J Crit Care. 2020 Feb:55:134-139. doi: 10.1016/j.jcrc.2019.10.014. Epub 2019 Oct 31.


Purpose: To assess the association of clinical variables and the development of specified chronic conditions in ICU survivors.

Materials and methods: A retrospective cohort study, combining a national health insurance claims database and a national quality registry for ICUs. Claims data from 2012 to 2014 were combined with clinical data of patients admitted to an ICU during 2013. To assess the association of clinical variables (ICU length of stay, mechanical ventilation, acute physiology score, reason for ICU admission, mean arterial pressure score and glucose score) and the development of chronic conditions (i.e. heart diseases, COPD or asthma, Diabetes mellitus type II, depression and kidney diseases), logistic regression was used.

Results: 49,004 ICU patients were included. ICU length of stay was associated with the development of heart diseases, asthma or COPD and depression. The reason for ICU admission was an important risk factor for the development of all chronic conditions with adjusted ORs ranging from 2.05 (CI 1.56; 2.69) for kidney diseases to 5.14 (CI 3.99; 6.62) for depression.

Conclusions: Clinical variables, especially the reason for ICU admission, are associated with the development of chronic conditions after ICU discharge. Therefore, these clinical variables should be considered when organizing follow-up care for ICU survivors.

Keywords: COPD; Chronic conditions; Depression; Diabetes mellitus type II; Heart diseases; ICU; Morbidity.

MeSH terms

  • Adult
  • Aged
  • Chronic Disease / epidemiology*
  • Critical Care / methods*
  • Female
  • Follow-Up Studies
  • Heart Diseases
  • Hospitalization*
  • Humans
  • Insurance Claim Review
  • Insurance, Health
  • Intensive Care Units
  • Length of Stay
  • Logistic Models
  • Male
  • Middle Aged
  • Netherlands / epidemiology
  • Patient Discharge
  • Registries
  • Respiration, Artificial / methods*
  • Retrospective Studies
  • Risk Factors
  • Survivors*