Axo-glial interdependence in peripheral nerve development

Development. 2019 Nov 12;146(21):dev151704. doi: 10.1242/dev.151704.


During the development of the peripheral nervous system, axons and myelinating Schwann cells form a unique symbiotic unit, which is realized by a finely tuned network of molecular signals and reciprocal interactions. The importance of this complex interplay becomes evident after injury or in diseases in which aspects of axo-glial interaction are perturbed. This Review focuses on the specific interdependence of axons and Schwann cells in peripheral nerve development that enables axonal outgrowth, Schwann cell lineage progression, radial sorting and, finally, formation and maintenance of the myelin sheath.

Keywords: Axons; Peripheral nerve; Schwann cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Cell Differentiation
  • Cell Lineage
  • Cell Separation
  • Gene Expression Regulation, Developmental*
  • Mice
  • Myelin Sheath / physiology*
  • Nerve Regeneration
  • Neuroglia / physiology*
  • Peripheral Nerves / embryology*
  • Peripheral Nerves / physiology
  • Peripheral Nervous System
  • Rats
  • Schwann Cells / physiology*
  • Signal Transduction