Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease

J Orthop Res. 2020 Apr;38(4):708-718. doi: 10.1002/jor.24523. Epub 2019 Nov 25.


In this review, we highlight themes from a recent workshop focused on "Plasticity of Cell Fate in Musculoskeletal Tissues" held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal development, regeneration, and disease. A thorough understanding of the biology underpinning mesenchymal cell plasticity may offer a roadmap for promoting regeneration while attenuating pathologic differentiation. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:708-718, 2020.

Keywords: heterotopic ossification; mesenchymal plasticity; musculoskeletal development; regeneration; transdifferentiation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Plasticity*
  • Disease
  • Humans
  • Musculoskeletal Development*
  • Myositis Ossificans / genetics
  • Ossification, Heterotopic / etiology
  • Regeneration
  • Wounds and Injuries / complications