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, 11 (9), e5776

G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated With Overweight and Dyslipidemia in Young Northeastern Mexicans

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G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated With Overweight and Dyslipidemia in Young Northeastern Mexicans

Ismael Rodríguez-Rodríguez et al. Cureus.

Abstract

There is extensive evidence to believe that the endocannabinoid system plays an important role in energy homeostasis through a variety of mechanisms. This study aimed to analyze the association between polymorphism rs12720071 of the cannabinoid type 1 receptor (CNR1) gene with dyslipidemia and overweight in young, healthy Mexicans. The association was analyzed with a logistic regression model and expressed as odds ratio (OR). A total of 148 individuals agreed to participate. Overall, the serum concentrations of lipids were found to be in the normal range. However, females presented higher levels of cholesterol and low-density lipoprotein (LDL) than males [probability value (p) = <0.05]. In addition, females presented higher risk of being overweight (BMI: >25) [OR = 3.57; 95% confidence interval (CI): 1.05-12.20; p = 0.04], than males. Our results suggest that this polymorphism could influence BMI in young females.

Keywords: cannabis receptor; gene polymorphism; mexico; serum lipids; young.

Conflict of interest statement

The authors have declared that no competing interests exist.

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