Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes

Prostaglandins Other Lipid Mediat. 2020 Apr;147:106398. doi: 10.1016/j.prostaglandins.2019.106398. Epub 2019 Nov 11.


Individuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize pro-inflammatory and pro-resolving (i.e., mediators involved in the resolution of inflammation) lipid mediators in individuals with TB and TB-DM. A nested cross-sectional study of 40 individuals (20 newly diagnosed DM and 20 without DM) was conducted within a cohort of individuals with active drug-susceptible treatment-naïve pulmonary TB. Lipid mediators were quantified in serum samples through lipid mediator profiling. We conducted correlation-based analysis of these mediators. Overall, the arachidonic acid-derived leukotriene and prostaglandin families were the most abundant pro-inflammatory lipid mediators, while lipoxins and maresins families were the most abundant pro-resolving lipid mediators in individuals with TB and TB-DM. Individuals with TB-DM had increased correlations and connectivity with both pro-inflammatory and pro-resolving lipid mediators compared to those with TB alone. We identified the most abundant lipid mediator metabolomes in circulation among individuals with TB and TB-DM; in addition, our data shows a substantial number of significant correlations between both pro-inflammatory and pro-resolving lipid mediators in individuals with TB-DM, delineating a molecular balance that potentially defines this comorbidity.

Keywords: Diabetes; Inflammation; Leukotrienes; Lipids; Lipoxins; Prostaglandins; Resolvins; Specialized pro-resolving mediators; Tuberculosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood*
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / immunology*
  • Diabetes Mellitus, Type 2 / pathology
  • Docosahexaenoic Acids / blood
  • Female
  • Humans
  • Inflammation / immunology*
  • Inflammation Mediators / blood*
  • Inflammation Mediators / immunology
  • Leukotrienes / blood
  • Lipoxins / blood
  • Male
  • Middle Aged
  • Prostaglandins / blood
  • Tuberculosis / blood
  • Tuberculosis / complications
  • Tuberculosis / immunology*
  • Tuberculosis / pathology


  • Biomarkers
  • Inflammation Mediators
  • Leukotrienes
  • Lipoxins
  • Prostaglandins
  • Docosahexaenoic Acids