Leiomyosarcoma of the skin: review of the literature with an emphasis on prognosis and management

Int J Dermatol. 2020 Feb;59(2):165-172. doi: 10.1111/ijd.14705. Epub 2019 Nov 14.


Leiomyosarcoma (LMS) of the skin is rare, and no management guideline currently exists. Although LMS is historically classified as either dermal (cutaneous) or subcutaneous, definition for its classfication is inconsistent in the literature. Studies on the managenent of LMS are scarce, and there is no consensus on the appropriate surgical margin for the treatment of LMS. While a 1 cm margin may be sufficient in cutaneous LMS, wider margins may be required for subcutaneous tumors. Mohs micrographic surgery is a promising surgical modality for the treatment of cutaneous LMS. In this review, current knowledge on LMS is summarized and a practical approach to the management of this rare neoplasm is proposed.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Chemotherapy, Adjuvant
  • Humans
  • Leiomyosarcoma / diagnosis
  • Leiomyosarcoma / epidemiology
  • Leiomyosarcoma / pathology*
  • Leiomyosarcoma / therapy*
  • Margins of Excision
  • Mohs Surgery
  • Neoplasm Staging
  • Prognosis
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / therapy*