Effects of fenfluramine, m-chlorophenylpiperazine, and other serotonin-related agonists and antagonists on penile erections in nonhuman primates

Life Sci. 1988;43(16):1297-303. doi: 10.1016/0024-3205(88)90584-x.


Fenfluramine, m-chlorophenylpiperazine (m-CPP), 1-phenylpiperazine, and the buspirone metabolite, 1-(2-pyrimidyl)piperazine given intravenously to adult rhesus monkeys regularly elicited penile erections. In contrast, serotonin (5-HT) agonists with 5-HT1A site specificity (8-OH-DPAT, buspirone) as well as trazodone, ritanserin, and metergoline were no different from saline in producing penile erections. Fenfluramine's effects were blocked by the 5-HT2 antagonists, ritanserin and metergoline, while m-CPP's effects were not blocked by the peripheral 5-HT antagonist, xylamidine, indicating that tumescence can be elicited by serotonergic agents which act at non-5-HT1A sites in the central nervous system.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Fenfluramine / pharmacology*
  • Macaca / physiology*
  • Macaca mulatta / physiology*
  • Male
  • Penile Erection / drug effects*
  • Piperazines / pharmacology*
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / physiology*


  • Piperazines
  • Receptors, Serotonin
  • Fenfluramine
  • 1-(3-chlorophenyl)piperazine