Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates

Molecules. 2019 Oct 25;24(21):3846. doi: 10.3390/molecules24213846.


A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.

Keywords: 5-acylamino-1,3-thiazoles; Hantzsch reaction; α-chloroglycinates.

MeSH terms

  • Catalysis
  • Cyclization*
  • Molecular Structure*
  • Thiazoles / chemical synthesis*
  • Thiazoles / chemistry


  • Thiazoles