[Endogenous and exogenous estrogens]

Presse Med. 2019 Nov;48(11 Pt 1):1244-1248. doi: 10.1016/j.lpm.2019.10.008. Epub 2019 Nov 12.
[Article in French]

Abstract

Before menopause, women are protected from the risk of hypertension and atherosclerosis by endogenous estrogens. Estrogens have a vasoprotective role, while progesterone seems to have a neutral effect. Exogenous estrogens used in menopausal treatment have vascular effects. These effects depend of type, dose and administration type, and with age and atherosclerosis stages. Synthetic progestins have varying clinical effects. Each drug must be evaluated separately.

Publication types

  • Review

MeSH terms

  • Arteries / drug effects
  • Arteries / physiology
  • Atherosclerosis / prevention & control*
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Estrogen Replacement Therapy
  • Estrogens / pharmacology*
  • Estrogens / physiology*
  • Ethinyl Estradiol / pharmacokinetics
  • Ethinyl Estradiol / pharmacology
  • Female
  • Humans
  • Hypertension / prevention & control*
  • Menopause / physiology
  • Premenopause* / physiology
  • Progesterone / physiology
  • Progestins / pharmacology*
  • Selective Estrogen Receptor Modulators / pharmacology

Substances

  • Estrogens
  • Progestins
  • Selective Estrogen Receptor Modulators
  • Ethinyl Estradiol
  • Progesterone