Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis

Hirofumi Inoue; Takeshi Matsushige; Takashi Ichiyama; Alato Okuno; Osamu Takikawa; Shozo Tomonaga; Banu Anlar; Deniz Yüksel; Yasushi Otsuka; Fumitaka Kohno; Madoka Hoshide; Shouichi Ohga; Shunji Hasegawa

doi:10.1016/j.jneuroim.2019.577088

Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis

J Neuroimmunol. 2020 Feb 15:339:577088. doi: 10.1016/j.jneuroim.2019.577088. Epub 2019 Oct 18.

Authors

Affiliations

¹ Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan.
² Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan. Electronic address: matsu@yamaguchi-u.ac.jp.
³ Division of Pediatrics, Tsudumigaura medical center for children with disabilities, Yamaguchi 745-0801, Japan.
⁴ Faculty of Medical and Health Sciences, Tsukuba International University, Ibaraki 300-0051, Japan; Division of Medical Informatics and Bioinformatics, Kobe University Hospital, Hyogo 650-0017, Japan.
⁵ Department of Research Promotion, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan.
⁶ Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8501, Japan.
⁷ Department of Pediatric Neurology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
⁸ Department of Pediatric Neurology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
⁹ Department of Neurology, Toki General Hospital, Gifu 509-5193, Japan.
¹⁰ Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan; Division of Pediatrics, Tsudumigaura medical center for children with disabilities, Yamaguchi 745-0801, Japan.
¹¹ Department of Pediatrics, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan.

PMID: 31733567
DOI: 10.1016/j.jneuroim.2019.577088

Abstract

Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.

Keywords: Indoleamine-2, 3-dioxygenase; Kynurenine pathway; Quinolinic acid; Subacute sclerosing panencephalitis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Biomarkers / cerebrospinal fluid
Child
Child, Preschool
Electroencephalography / methods
Female
Follow-Up Studies
Humans
Male
Quinolinic Acid / cerebrospinal fluid*
Subacute Sclerosing Panencephalitis / cerebrospinal fluid*
Subacute Sclerosing Panencephalitis / diagnosis*
Subacute Sclerosing Panencephalitis / physiopathology
Young Adult

Substances

Biomarkers
Quinolinic Acid