The Future of Biomarkers

Crit Care Clin. 2020 Jan;36(1):177-187. doi: 10.1016/j.ccc.2019.08.014.


Numerous compounds have been tested as potential biomarkers for multiple possible applications within intensive care medicine but none is or will ever be sufficiently specific or sensitive for the heterogeneous syndromes of critical illness. New technology and access to huge patient databases are providing new biomarker options and the focus is shifting to combinations of several or multiple biomarkers rather than the single markers that research has concentrated on in the past. Biomarkers will increasingly be used as part of routine clinical practice in the future, complementing clinical examination and physician expertise to provide accurate disease diagnosis, prediction of complications, personalized treatment guidance, and prognosis.

Keywords: Biomarker panels; Phenotypes; Precision medicine; Sensitivity; Specificity.

Publication types

  • Review

MeSH terms

  • Biomarkers / blood*
  • Critical Care / methods*
  • Critical Care / trends*
  • Forecasting
  • Humans
  • Precision Medicine / methods*
  • Precision Medicine / trends*
  • Predictive Value of Tests
  • Prognosis
  • Reproducibility of Results
  • Sensitivity and Specificity


  • Biomarkers