Orthostatic Hypotension in Parkinson Disease

Clin Geriatr Med. 2020 Feb;36(1):53-67. doi: 10.1016/j.cger.2019.09.002. Epub 2019 Sep 6.


Orthostatic hypotension (OH) is a sustained fall in blood pressure on standing that can cause symptoms of organ hypoperfusion. OH is associated with increased morbidity and mortality and leads to a significant number of hospital admissions. OH can be caused by volume depletion, blood loss, cardiac pump failure, large varicose veins, medications, or defective activation of sympathetic nerves and reduced norepinephrine release upon standing. Neurogenic OH is a frequent and disabling problem in patients with synucleinopathies such as Parkinson disease, multiple system atrophy, and pure autonomic failure, and it is commonly associated with supine hypertension. Several therapeutic options are available.

Keywords: Autonomic failure; Baroreflex dysfunction; Droxidopa; Midodrine; Neurogenic orthostatic hypotension; Norepinephrine.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aged
  • Humans
  • Hypotension, Orthostatic* / etiology
  • Hypotension, Orthostatic* / therapy
  • Parkinson Disease* / physiopathology
  • Parkinson Disease* / therapy
  • Patient Care Management / methods*