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Review
. 2020 Apr;105:103539.
doi: 10.1016/j.dci.2019.103539. Epub 2019 Nov 14.

Dscam in Immunity: A Question of Diversity in Insects and Crustaceans

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Review

Dscam in Immunity: A Question of Diversity in Insects and Crustaceans

Tze Hann Ng et al. Dev Comp Immunol. .

Abstract

In insects and crustaceans, thousands of Down syndrome cell adhesion molecules (Dscam) can be generated by alternative splicing of variable exons from a single-locus gene, Dscam-hv. This extraordinarily versatile gene (38,016 protein isoforms produced in Drosophila) was first proposed to be involved in exon guidance and subsequently implicated in immunity as a hypervariable immune molecule. Almost 20 y after discovery of Dscam-hv, there have been many studies in insects and crustaceans regarding roles of Dscam in immunity, with many similarities and concurrently, many differences. Here, we review the current status of Dscam-hv, presented as a comparison of similarities and differences in insects and crustaceans and discuss hypotheses of Dscam functions in immunity.

Keywords: Crustaceans; Dscam; Immune priming; Innate immune memory; Insects; Invertebrate immunity.

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