The Impact of Obesity in Heart Failure

Heart Fail Clin. 2020 Jan;16(1):71-80. doi: 10.1016/j.hfc.2019.08.008.


Obesity has reached worldwide epidemic proportions, adversely impacting health on a global scale. Overweight and obesity adversely impact cardiac structure and function, affecting systolic and diastolic ventricular function. Studies and meta-analyses have documented an obesity paradox in large heart failure cohorts, where overweight and obese individuals with established heart failure have a better short- and medium-term prognosis compared with lean patients; this relationship is strongly impacted by level of cardiorespiratory fitness. There are implications for therapies aimed at increasing lean and muscle mass, and weight loss, for the prevention and treatment of compared with in patients with concomitant obesity.

Keywords: Body composition; Cardiorespiratory fitness; Heart failure; Obesity; Obesity paradox.

Publication types

  • Review

MeSH terms

  • Body Mass Index
  • Global Health
  • Health Status*
  • Heart Failure / epidemiology
  • Heart Failure / etiology*
  • Heart Failure / physiopathology
  • Humans
  • Obesity / complications*
  • Obesity / physiopathology
  • Prevalence
  • Prognosis
  • Risk Factors
  • Stroke Volume / physiology*