Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 58 (22), 3219-3225

The Relationship Between Circulating Polyunsaturated Fatty Acid Levels and Exercise Responses of Patients With Non-ischemic Heart Failure

Affiliations

The Relationship Between Circulating Polyunsaturated Fatty Acid Levels and Exercise Responses of Patients With Non-ischemic Heart Failure

Seiya Izumida et al. Intern Med.

Abstract

Objective Polyunsaturated fatty acids (PUFAs) are associated with heart failure (HF) as well as coronary artery disease. However, little is known about the relationships between PUFAs and the exercise responses of patients with HF. We evaluated the relationships between PUFAs and the parameters of cardiopulmonary exercise tests (CPETs) in patients with non-ischemic HF. Methods Fifty patients with stable non-ischemic HF underwent CPETs at our hospital. Data were analyzed to evaluate the relationships between PUFAs and echocardiographic findings as well as CPET and other test parameters. Results Correlations were significant and negative between dihomo-γ-linolenic acid (DGLA) + arachidonic acid (AA) and minute ventilation versus carbon dioxide production (VE/VCO2) slope, and positive between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and VE/VCO2 slope. A multivariate regression analysis selected DGLA+AA and AA as independent predictors of VE/VCO2 slope. However, eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) were not significantly correlated with the CPET parameters. Conclusion Low levels of circulating DGLA+AA and AA among PUFAs were associated with decreased exercise responses in patients with stable non-ischemic HF. These findings suggest that high levels of omega-6 PUFAs may improve the clinical outcomes of patients with non-ischemic HF via their effects on exercise responses.

Keywords: cardiopulmonary exercise test; diet; nutrition.

Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

Similar articles

See all similar articles

References

    1. Balady GJ, Arena R, Sietsema K, et al. Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation 122: 191-225, 2010. - PubMed
    1. Arena R, Guazzi M, Cahalin LP, Myers J. Revisiting cardiopulmonary exercise testing applications in heart failure: aligning evidence with clinical practice. Exerc Sport Sci Rev 42: 153-160, 2014. - PubMed
    1. Nadruz W Jr, West E, Sengelov M, et al. Prognostic value of cardiopulmonary exercise testing in heart failure with reduced, midrange, and preserved ejection fraction. J Am Heart Assoc 6: 2017. - PMC - PubMed
    1. Webster CM, Deline ML, Watts JL. Stress response pathways protect germ cells from omega-6 polyunsaturated fatty acid-mediated toxicity in Caenorhabditis elegans. Dev Biol 373: 14-25, 2013. - PMC - PubMed
    1. Iso H, Kobayashi M, Ishihara J, et al. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation 113: 195-202, 2006. - PubMed

Substances

Feedback